Endocrine Abstracts

Over past years various treatment options for osteoporosis have become available and withdrawn due to side effects or insufficient efficacy. This summary reviews sequential and combination therapy for osteoporosis with the currently approved first line treatments such as potent antiresorbtive (nitrogen-containing bisphosphonates (BP), denosumab (DM)) or anabolic agents (teriparatide, abaloparatide). We assume that all medications are taken with vitamin D and calcium supplement...

Aim: To present a clinical case of reversible hypopituitarism due to hypophysitis developed after COVID-19 infection.Materials and methods: A patient with residual clinical manifestations of hypopituitarism underwent clinical evaluation at the time of symptoms of hypopituitarism and in follow-up. Morning serum cortisol (171-536 nmol/l) was measured by electrochemiluminescence immunoassay. Morning ACTH (7.2-63.3 pg/ml), prolactin (66-436 mU/l), TSH (0.25-...

We report a 53-year-old man. At age 3, the patient was diagnosed with chronic mucocutaneous candidiasis. At age 41 the patient started losing all hair on the body with total boldness. At age 43, he first complained of muscle weakness resulting in difficulty walking, back pain and difficulties holding his head in an upright position. At age 49, he was diagnosed with chronic primary adrenal insufficiency and hypoparathyroidism. Genetic analysis confirmed APS-1 (c.769C>T p.R2...

According to numerous studies, type 2 diabetes mellitus (T2DM) is associated with an increased risk of low traumatic non-vertebral fracture. There are a limited number of studies which evaluate lateral vertebral X-Rays in order to diagnose vertebral fractures in patients with T2DM. The goal of our study was to investigate the difference in vertebral fracture rate registered on lateral X-Ray between subjects with T2DM and a control group being under observation in the same outp...

MELAS syndrome is a progressive neurodegenerative disorder characterized by a combination of mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes and endocrine disorders. The frequency of hypoparathyroidism in MELAS syndrome is less than 0.5%. A 22-year-old female was admitted to our center due to episodes of seizures. At admission her height was 147.5 cm, weight 30.5 kg, BMI 13.8 kg/m2. She reported whole life weight and growth retardation, hearin...

According to state statistics service, Russia’s population in 2018 is more than 146.8 mil people. The total prevalence of acromegaly may range between 2.8 and 13.7 cases per 100,000 people and the annual incidence rates vary between 0.2 and 1.1 cases per 100,000 people (Lavrentaki A, et al. 2016). The epidemiological data for acromegaly in Russian population is lacking. The Russian hypothalamic and pituitary tumors registry was founded in 2004 and for 2018 it con...

Introduction: Medical therapy with dopamine agonists is the best treatment for prolactinomas of any size or invasiveness and restores ovulatory cycles in 80–90% of patients. Cabergoline currently suggested nearly exclusively rather than other dopamine agonists due to its excellent tolerability and long half-life. That is why the question of safety using of this drug during pregnancy and embryo-fetal development is actual.Aim: The aim of the study is...

This study estimates the recovery of bone mineral density (BMD), markers of bone remodeling and quality of life in patients with endogenous Cushing’s syndrome (CS) after 12 months of remission.Materials and methods: Twenty-one patients with CS were prospectively evaluated at active stage of the disease and after being in a full remission (substitutional therapy with hydrocortisone or normal 24 h urinary free cortisol (24 h UFC) and late-night cortis...

Introduction: Osteopetrosis is a rare hereditary disease caused by defective osteoclast differentiation or function. Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for some forms of osteopetrosis. HSCT is usually performed in infancy. Currently there is also experience of HSCT for osteopetrosis in adults1. In this clinical case we describe the follow-up of a patient treated with HSCT1 at the age of 28.<p class="abst...

Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is a rare, autosomal dominant disease caused by mutations in the MEN1 gene. The syndrome predisposes an individual to the development of primary hyperparathyroidism (PHPT), gastroenteropancreatic neuroendocrine tumors (GEP-NETs), pituitary adenomas (PA), as well as other endocrine and non-endocrine tumors that usually manifest at a young age. If a patient with the MEN 1 phenotype does not carry m...